DNA Celiac Disease Test

$325.00

Almost all people with celiac disease carry at least one genetic risk allele. Find out your risk with this DNA test.

 

  • Includes HLA variants associated with increased risk
  • Negative results rules out celiac disease for life
  • Accurate even on a gluten-free diet
  • No age limit
  • 24/7 online status check
  • Are you at increased risk of celiac disease?

DESCRIPTION

What is celiac disease?

Celiac disease is an autoimmune disorder in which the immune system mistakenly attacks and damages healthy cells. Individuals with this condition are highly sensitive to gluten, a protein present in wheat, rye, barley, and oats.

When someone with celiac disease consumes gluten, their immune system reacts abnormally, causing severe damage to the lining of the small intestine and leading to various health complications.

It is important to note that this genetic analysis does not require the consumption of gluten. A simple DNA sample from a mouth swab is all that is necessary for an accurate result.

THE GENETICS

Genetic Risk Factors for Celiac Disease

Almost all people with celiac disease have at least one genetic risk allele in their HLA genes. This DNA test detects nucleotide changes that occur in the three CD-associated alleles of the HLA-DQA1 and HLA-DQB1 genes (HLA-DQA1*05, HLA-DQB1*02, HLA-DQB1*0302).

These CD-associated variants can also pair together to form proteins known as DQ2 and DQ8. The presence or absence of these variants gives an indication of the risk of gluten sensitivity and CD. The risk of CD is extremely low if none of these CD-associated alleles are present.

Celiac Disease Risk Based on Genotype
Patient Genotype (celiac-associated alleles present) Celiac Disease Risk
DQ2 and DQ8 1:7
DQ2 and Homozygous HLA-DQB1*02 1:10
DQ2 and DQ2 1:10
DQ8 and DQ8 1:12
DQ8 and HLA-DQB1*02 1:24
Homozygous HLA-DQB1*02 1:26
DQ2 1:35
DQ8 1:89
Heterozygous HLA-DQB1*02 1:210
HLA-DQA1*05 1:1842
No HLA celiac-associated alleles detected Not at risk of developing celiac disease, less than 1:2518

DIGESTIVE SYMPTOMS OF CELIAC DISEASE

  • Flatulence
  • Bloating
  • Constipation and/or diarrhea
  • Appetite changes
  • Pale or bloody stools
  • Nausea and vomiting

HOW IT WORKS

Step 1: Order test kit online
Step 2: Collect DNA sample using a painless mouth swab, and mail to the lab in the provided return envelope
Step 3: Receive your results online

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